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. 2021 Nov 1;35(21-22):1403–1430. doi: 10.1101/gad.348897.121

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© 2021 Alendar and Berns; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Cell fate specification and lineage commitment. CHD functions are important in diverse stem cell populations (annotated by yellow rectangles). Some CHDs are important for the emergence and self-renewal of stem cells (circular arrow), and others are vital for lineage commitment and differentiation (straight arrows). Distinct CHDs can promote (black) or inhibit (red) differentiation. For simplicity, not all intermediate precursors and terminally differentiated cells are depicted. (ESC) Embryonic stem cell, (HSC) hematopoietic stem cell, (MSC) mesenchymal stem cell, (NSC) neural stem cell, (NCSC) neural crest stem cell, (DFC) dental follicle cells.