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. 2021 Oct 26;48(6):222. doi: 10.3892/ijmm.2021.5055

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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ISLR suppresses the aerobic glycolysis of NSCLC cells. (A) Glucose uptake (B) lactate production and (C) ATP/ADP ratios were analysed after A549 and H1299 cells were transfected with si-ISLR or pcDNA3.1-ISLR, respectively. (D) Glycolytic target protein expression levels. ^*P<0.05 vs. control group; ^#P<0.05 vs. si-NC group; ^{^}P<0.05 vs. pcDNA3.1-NC group. ISLR, immunoglobulin superfamily containing leucine-rich repeat; NC, negative control; si, small interfering RNA; HK-2, hexokinase 2; Glut-1, glucose transporter 1; LDHA, lactate dehydrogenase A.