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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Adv Drug Deliv Rev. 2020 Jun 29;156:188–213. doi: 10.1016/j.addr.2020.06.020

Fig. 14.

Fig. 14.

(top) Schematic depiction of hexagonal cobalt- and manganese-doped iron oxide nanoparticles encapsulated within polymeric nanocarriers. (bottom) (a) Representative intratumoral temperature profiles during AMF (420 kHz, 26.9 kA/m) exposure of mice injected with a single dose of 5% dextrose (AMF), cobalt and manganese-doped iron oxide nanoclusters (Co-Mn-IONP), and IONP nanoclusters. The navy curve shows the intratumoral temperature during the fourth cycle in a mouse that was treated with CoMn-IONP nanoclusters (6 mg Fe/kg) and AMF once a week for 4 weeks. (b) Tumor growth profiles of mice with ES-2 xenografts after four cycles of the following treatments; *p < 0.05 when compared with nontreated animals. (c) Tumor growth profiles of mice with ES-2 xenografts after treatment with AMF for 10 min. or 40 min. (Adapted from ref. 291).