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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Adv Drug Deliv Rev. 2020 Jun 29;156:188–213. doi: 10.1016/j.addr.2020.06.020

Fig. 4.

Fig. 4.

(a) Schematic depiction of the synthesis of polyvalent RNA-AuNP conjugates. (b) Knockdown of luciferase expression in HeLa cells over 4 days using polyvalent RNA–AuNP conjugates (3 nmol/L nanoparticle (NP) concentration, ~100 nmol/l RNA duplex concentration) or double-stranded (ds) RNA (100 nmol/l). (c) Stability of RNA–AuNPs. Comparison of the stability of cyanine 5-labeled double-stranded (ds)RNA (red) and RNA–AuNPs (blue) in 10% serum. The increase in fluorescence intensity demonstrates the distance-dependent release of the fluorophore from the gold core, which is an efficient quencher of the fluorescence. (Adapted from ref. 107).