Table 3.
Baselines | Statistical Models | Causal Models | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||
Adverse event type [+ ctrls, − ctrls] | ROR | χ 2 | ||||||||
Acute kidney failure [10+, 9−] | 0.6222 | 0.4667 | 0.6 | 0.7444 | 0.5667 | 0.6222 | 0.5 | 0.8111 † | 0.5111 | 0.5 |
| ||||||||||
Acute liver failure [43+, 11−] | 0.5835 | 0.5814 | 0.6004 | 0.6723 | 0.4905 | 0.6765 † | 0.4926 | 0.5243 | 0.5433 | 0.5624 |
| ||||||||||
Acute myocardial infarction [15+, 23−] | 0.6261 | 0.6754 | 0.658 | 0.5159 | 0.4783 | 0.5217 | 0.6 | 0.6725 | 0.6667 | 0.6464 |
| ||||||||||
Gastrointestinal hemorrhage [20+, 32−] | 0.5688 | 0.6 | 0.5672 | 0.7078 | 0.5688 | 0.7156 † | 0.5484 | 0.55 | 0.5203 | 0.4891 |
| ||||||||||
Weighted overall AUROC [88+, 75−] | 0.5933 | 0.5959 | 0.6032 | 0.6556 † | 0.5363 | 0.6005 | 0.5215 | 0.6466 | 0.561 | 0.5513 |
χ2 = chi squared. β = coefficient from multiple variable logistic regression. Δ = average treatment effect using graphical causal models. Results exceeding best baseline performance are in boldface.
indicates best performance for a side effect.