Table 5.
Baselines | Statistical Models | Causal Models | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Adverse Event Type [+ ctrls, − ctrls] | ROR | χ 2 | ||||||||
K = 10 | ||||||||||
Acute kidney failure [10+, 9−] | 0.4756 | 0.4921 | 0.4106 | 0.3068 | 0.4768 | 0.4135 | 0.5378 | 0.7032 † | 0.4756 | 0.5653 |
Acute liver failure [43+, 11−] | 0.8955 | 0.8917 | 0.8389 | 0.7579 | 0.8803 | 0.725 | 0.7972 | 0.8951 | 0.6815 | 0.9627 † |
Acute myocardial infarction [15+, 23−] | 0.4889 | 0.5981 | 0.4974 | 0.4021 | 0.4911 | 0.4155 | 0.5193 | 0.8529 † | 0.7296 | 0.5883 |
Gastrointestinal hemorrhage [20+, 32−] | 0.5556 | NA | NA | NA | 0.1 | 0.125 | NA | 0.325 | 0.125 | 0.2 |
K = 25 | ||||||||||
Acute kidney failure [10+, 9−] | 0.4866 | 0.515 | 0.4751 | 0.4166 | 0.5057 | 0.4665 | 0.5422 | 0.7277 † | 0.5229 | 0.5477 |
Acute liver failure [43+, 11−] | 0.7993 | 0.7863 | 0.7767 | 0.7132 | 0.8449 | 0.7067 | 0.8163 | 0.8764 | 0.7085 | 0.9051 † |
Acute myocardial infarction [15+, 23−] | 0.3795 | 0.6056 | 0.54 | 0.4227 | 0.455 | 0.4261 | 0.5092 | 0.6715 † | 0.6595 | 0.5618 |
Gastrointestinal hemorrhage [20+, 32−] | 0.4258† | 0.2093 | 0.224 | 0.1937 | 0.255 | 0.1857 | 0.3025 | 0.3739 | 0.2361 | 0.2626 |
ROR = reporting odds ratio. χ2 = chi squared. β = generalized linear models (multiple variable logistic regression). Δ = average treatment effect using graphical causal models. Results exceeding best baseline performance are in boldface.
indicates best performance for a side effect.