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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: J Biomed Inform. 2021 Mar 11;117:103719. doi: 10.1016/j.jbi.2021.103719

Table 5.

Mean Average Precision at K.

Baselines Statistical Models Causal Models
Adverse Event Type [+ ctrls, − ctrls] ROR χ 2 βsql5 βpsi5 βsql10 βpsi10 Δsql5 Δpsi5 Δsql10 Δpsi10
K = 10
Acute kidney failure [10+, 9−] 0.4756 0.4921 0.4106 0.3068 0.4768 0.4135 0.5378 0.7032 0.4756 0.5653
Acute liver failure [43+, 11−] 0.8955 0.8917 0.8389 0.7579 0.8803 0.725 0.7972 0.8951 0.6815 0.9627
Acute myocardial infarction [15+, 23−] 0.4889 0.5981 0.4974 0.4021 0.4911 0.4155 0.5193 0.8529 0.7296 0.5883
Gastrointestinal hemorrhage [20+, 32−] 0.5556 NA NA NA 0.1 0.125 NA 0.325 0.125 0.2
K = 25
Acute kidney failure [10+, 9−] 0.4866 0.515 0.4751 0.4166 0.5057 0.4665 0.5422 0.7277 0.5229 0.5477
Acute liver failure [43+, 11−] 0.7993 0.7863 0.7767 0.7132 0.8449 0.7067 0.8163 0.8764 0.7085 0.9051
Acute myocardial infarction [15+, 23−] 0.3795 0.6056 0.54 0.4227 0.455 0.4261 0.5092 0.6715 0.6595 0.5618
Gastrointestinal hemorrhage [20+, 32−] 0.4258 0.2093 0.224 0.1937 0.255 0.1857 0.3025 0.3739 0.2361 0.2626

ROR = reporting odds ratio. χ2 = chi squared. β = generalized linear models (multiple variable logistic regression). Δ = average treatment effect using graphical causal models. Results exceeding best baseline performance are in boldface.

indicates best performance for a side effect.