Table 1.
Parameter Estimates for Decision Analytic Model
| Parameter | Base-Case Value, % (Range) | Reference(s) |
|---|---|---|
| Prevalence of Staphylococcus aureus colonizationa | 30.0 (15.0–36.0) | Kline et al,14 Wertheim et al,19 Tong et al,28 Botelho-Nevers et al9 |
| Monthly probability of natural S. aureus clearance | 3.6 (2.5–6.7) | Miller et al17 |
| Monthly probability of S. aureus acquisition | 1.5 (1.3–1.8) | Miller et al17 |
| S. aureus culture sensitivity | 88.0 (82.0–92.0) | Luteijn et al16 |
| S. aureus culture specificity | 95.0 (91.0–97.0) | Luteijn et al16 |
| Probability of SSI given no colonization with S. aureus | 2.0 (1.0–5.0) | Magill et al,15 Urban et al.29 |
| RR of SSI given colonization with S. aureus | 4.5 (2.0–10.0)b | Simor20 Bode et al21 |
| Bundle efficacy | 71.9 (58.5–83.0) | Kline et al14 |
| Standard of care efficacy | 24.5 (13.8–38.3) | Kline et al14 |
| Probability of death from SSI | 1.0 (0.3–5.0) | Berger et al,23 Kirkland et al30 |
Note. SSI, surgical site infection; RR, relative risk.
a
Nasal, throat, axillary, and/or perianal area.
b
This is a multiplier of probability of SSI given no colonization with S. aureus (relative risk).