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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: J Am Coll Cardiol. 2019 Jun 18;73(23):3006–3017. doi: 10.1016/j.jacc.2019.04.015

FIGURE 2. Schematic of Possible Connections Among Different Neural Structures.

FIGURE 2

There are multiple pathways through which renal denervation can directly and indirectly result in brain stem and stellate ganglion remodeling and reduced nerve activity. These include inhibition of afferent nerve signaling (green lines) and retrograde trans-synaptic degeneration (blue lines) (28).