Table 3.

Comparing and contrasting features of MIS-C and KD^*

Guidance statement	Level of consensus
Patients with KD that is unrelated to SARS-CoV-2 will continue to require evaluation, diagnosis, and treatment during the SARS-CoV-2 pandemic.	High
MIS-C and KD unrelated to SARS-CoV-2 infections may share overlapping clinical features, including conjunctival infection, oropharyngeal findings (red and/or cracked lips, strawberry tongue), rash, swollen and/or erythematous hands and feet, and cervical lymphadenopathy.	Moderate to high
Several epidemiologic, clinical, and laboratory features of MIS-C may differ from KD unrelated to SARS-CoV-2 in the following ways:  1. There is an increased incidence of MIS-C in patients of African, Afro-Caribbean, and Hispanic descent, but a lower incidence in those of East Asian descent.  2. Patients with MIS-C encompass a broader age range, have more prominent GI and neurologic symptoms, present more frequently in a state of shock, and are more likely to display cardiac dysfunction (arrhythmias and ventricular dysfunction) than children with KD.  3. At presentation, patients with MIS-C tend to have lower platelet counts, lower absolute lymphocyte counts, and higher CRP levels than patients with KD.	Moderate to high
Epidemiologic studies of MIS-C suggest that younger children are more likely to present with KD-like features, while older children are more likely to develop myocarditis and shock.	Moderate
It is unknown if the incidence of CAAs is different in MIS-C compared to KD; however, MIS-C patients without KD features can develop CAAs.	Moderate to high

^*MIS-C = multisystem inflammatory syndrome in children; KD = Kawasaki disease; SARS–CoV-2 = severe acute respiratory syndrome coronavirus 2; GI = gastrointestinal; CRP = C-reactive protein; CAAs = coronary artery aneurysms.