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. Author manuscript; available in PMC: 2022 Nov 15.
Published in final edited form as: Arch Biochem Biophys. 2021 Sep 15;712:109025. doi: 10.1016/j.abb.2021.109025

Fig. 2.

Fig. 2.

Tunnel system of PutA and dynamics of the PRODH site. (A) Ribbon drawing of a dimer of the resting state of Geobacter sulfurreducens PutA (GsPutA, PDB ID 4NM9) with the tunnel system represented as surfaces. The two protomers are colored pink and cyan. (B) Close-up view of the tunnel system. The dashed curve shows the direction of channeling of P5C/GSAL through the main tunnel. The six tributary tunnels, which connect the main tunnel to the protein surface, are colored green (tunnel 1), silver (2a), yellow (2b), blue (3a, 3b), and brown (4). (C) Conformational changes in the PRODH site associated with the binding of the proline analog THFA. Residues of the conserved ion pair are colored pink (Glu149) and blue (Arg421). Left: resting enzyme with no ligand in the PRODH site (PDB ID 4NM9). Right: complexed with the proline analog THFA (PDB ID 4NMA).