Table 3.
Linear regression models for the association between serum levels of phenylalanine and inflammatory markers, adjusted for sex, age, comorbidity (CCI), and disease severity groups.
| Dependent variable: Phenylalanine (log mg/dL) |
||||||
|---|---|---|---|---|---|---|
| Independent variables | Model 1 |
Model 2 |
Model 3 |
|||
| Standardized β Coefficient (95% CI) |
p | Standardized β Coefficient (95% CI) |
p | Standardized β Coefficient (95% CI) |
p | |
| IL-2 (log pg/mL) | 0.06 (−0.09 to 0.21) | 0.4 | – | – | – | – |
| IL-6 (log pg/mL) | – | – | 0.13 (−0.02 to 0.28) | 0.08 | – | – |
| IL-10 (log pg/mL) | – | – | – | – | 0.09 (−0.06 to 0.24) | 0.2 |
| Male sex | 0.07 (−0.23 to 0.39) | 0.1 | 0.09 (−0.21 to 0.4) | 0.5 | 0.08 (−0.22 to 0.39) | 0.5 |
| Age, years | 0.12 (−0.15 to 0.39) | 0.3 | 0.11 (−0.6 to 0.38) | 0.4 | 0.11 (−0.16 to 0.38) | 0.4 |
| Charlson Comorbidity Index | −0.03 (−0.3 to 0.24) | 0.8 | −0.01 (−0.28 to 0.25) | 0.9 | −0.01 (0.28 to 0.25) | 0.9 |
| Disease severity | ||||||
| Mild | Reference | – | Reference | – | Reference | – |
| Moderate | 0.73 (0.23–1.22) | 0.004 | 0.70 (0.22–1.19) | 0.005 | 0.70 (0.21–1.19) | 0.005 |
| Severe | 0.91 (0.39–1.43) | <0.001 | 0.85 (0.34–1.37) | 0.001 | 0.86 (0.35–1.38) | 0.001 |
95% CI, 95% Confidence Interval.