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. 2021 Oct 18;11:753119. doi: 10.3389/fonc.2021.753119

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Copyright © 2021 Liao, Qian, Zhang, Tao, Li, Zhang, Liang, Li, Xie, Zhuo, Chen, Jiang, Cao, Niu, Xue, Ni, Pan and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ARV-825 induces cell cycle block and apoptosis of gastric cancer cells. (A) ARV-825 increased ratio of G1 phase cells and simultaneously decreased the ratio of S phase and G2 phase cells in MGC803, HGC27, AGS, and SGC7901 cells via cell cycle analysis. (B) The ratio of apoptotic cells among gastric cancer cells increased dose dependently after treated with ARV-825 via cell apoptosis analysis. (C) The ratio of apoptotic cells markedly elevated dose dependently in gastric cancer cells with ARV-825 treatment. **p < 0.01, ***p < 0.001.