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. 2021 Oct 18;11:753119. doi: 10.3389/fonc.2021.753119

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Copyright © 2021 Liao, Qian, Zhang, Tao, Li, Zhang, Liang, Li, Xie, Zhuo, Chen, Jiang, Cao, Niu, Xue, Ni, Pan and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme 1 — Schematic illustration of ARV-825 treating gastric cancer. (A) Technical roadmap of ARV-825 treating gastric cancer. (B) Schematic diagram of ARV-825 degrading BRD4. (C) Molecular mechanism of ARV-825 treating gastric cancer. Ub, ubiquitin; E2, ubiquitin-conjugating enzyme; cereblon, E3 ubiquitin ligase; Ac, acetylation modification site.