Fig. 1. Validation of transductions.
A, B Retrograde transduction of Cre-positive tyrosine hydroxylase (TH) expressing neurons in the dorsomedial striatum. C Immunohistochemical staining of mCherry in dorsomedial striatum and in substantia nigra. D Viral vectors used in the vehicle (mDS-mCherry) and chemogenetic (mDS-DREADD) transduction groups. E, G, I Fluorescent microscopy of mCherry (viral transducted) and TH-positive (dopamine) cells in the mesencephalon. F, H, J Magnifications of individual transducted cells (two examples labeled with white arrows) in the SN.