Fig. 4. [¹⁸F]FDG images and correlation analysis.

A [¹⁸F]FDG uptake in mDS-DREADD animal at baseline and after chemogenetic (CNO) stimulation (rainbow color), lower metabolic activity (blue color), higher metabolic activity (red color). B Regional standard uptake values at all conditions and C significant changes and individual animals in mDS, mPFC, and OFC. (♂ = ▴) (♀ = ▾). D Fisher-Z correlations in mDS-DREADD animals at baselines. E Similar correlations in mDS-DREADD animals after chemogenetic stimulations. F ΔZ values for each region, showing the total difference between correlations. Nucleus acumbens (NAc), medial dorsal striatum (mDS), lateral dorsal striatum (lDS), anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), thalamus (Thal), the midbrain including ventral tegmental area and substantia nigra (MB), hypthalamus (Hyp) and cerebellum (Cer).