Figure 2. Passive or active membrane properties of dentate granule cells remain unchanged in the dorsal hippocampus following intraperitoneal administration of all-trans retinoic acid (atRA).
(A, B) Group data of resting membrane potentials, input-output curves, and input resistances. (C) A slight but not significant decrease in action potential (AP) frequency of dentate granule cells is observed in the atRA group (ncontrol = 22 cells, natRA = 25 cells in four animals each; Mann-Whitney test for column statistics, RM two-way ANOVA followed by Sidak’s multiple comparisons test for input-output curve and AP frequency analysis). Individual data points are indicated by gray dots. Values represent mean ± SEM. (ns, non-significant difference).