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. 2021 Nov 1;10:e71983. doi: 10.7554/eLife.71983

Figure 3. All-trans retinoic acid (atRA) does not induce changes in excitatory and inhibitory neurotransmission in the ventral hippocampus of adult mice.

Figure 3.

(A) Example of patched and post hoc identified dentate granule cell in acute slices prepared from the ventral hippocampus. Scale bar (upper panel)=500 µm; Scale bar (lower panel)=50 µm. (B) Sample traces of spontaneous excitatory postsynaptic currents (sEPSCs) and spontaneous inhibitory postsynaptic currents (sIPSCs) recorded from dentate granule cells of atRA-treated or vehicle-only (control) animals. (C) Group data of sEPSC recordings (ncontrol=23 cells, natRA=23 cells in four animals each; Mann-Whitney test). (D) Group data of sIPSC recordings (ncontrol=34 cells, natRA=31 cells in four animals each; Mann-Whitney test). Individual data points are indicated by gray dots. Values represent mean ± SEM. (ns, non-significant difference). DG, dentate gyrus; gcl, granule cell layer; ml, molecular layer.