TABLE 1.
Umbilical cord blood transplantation for acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and aplastic anemia (AA)
| References | Diagnosis | Patients (n) | Graft" | Median age, years (range) | Neutrophil engraftment | Platelet engraftment (≥20 × 109/L) | Relapse | TRM | Grade II‐IV Acute GVHD | Chronic GVHD | Overall survival | Disease‐free survival |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Matsumura et al 7 | ALL | 256 | Single unit | 40 (16‐74) | 78% at day 100 | 64% at day 100 | 43% at 2 years | 35% | 37% | 24% at 2 years | 42% at 2 years | 36% at 2 years |
| Page et al 8 | ALL | 640 | Single unit | 6.4 (0.5‐17.9) | / | / | 26% | / | 40.4% | 17% at 5 years | 51.3% at 5 years | 47.4% at 5 years |
| Piñana et al 9 | PH + ALL | 45 | Single unit | 31 (3–47) | 96% at 44 days | 73% at 183 days | 31% at 5 years | 31%(18%–45%) at 5 years | 31% | 53% (36‐70%) at 5‐years | 44% (28‐60%) at 5 years | 36% at 5 years |
| Sanz et al 10 | High‐risk AML | 49 | Single unit | 34 (16‐52) | 96% at 57 days | 73% at 250 days | 19% at 2 years | 2‐year NRM: 39% | 26% | 46% at 2 years | 37% at 4 years | |
| Baron et al 11 | AML | 1068 | Single unit: 567, double units: 501 | 45.5 (18‐73) | 77% | / | 32% at 2 years | 38% at 2 years | 31% | 42% at 2 years | 32% at 2 years | 30% at 2 years |
| Yanada et al 12 | AML | 1355 | Single unit | 52 (16‐85) | / | / | 18.2% at 3 years | 29.5% at 3 years | / | / | 55.1% at 3 years | / |
| Madureira et al 13 | MDS | 70 | Single unit | 6 (<1‐17) | 76% at day 60 | 57% at day 180 | 13 of 70 | 53% prior to 2001 (n = 30); 31% after 2001 (n = 40) | 30% | 23% at 3 years | 42% at 3 years | 39% at 3 years |
| Robin et al 14 | MDS | 129 | Single unit: 49, Double units: 80 | 57 (20‐72) | 78% | / | 30% | 42% at 2 years | 31% | 23% | 30% | 28% ± 4% |
| Gerds et al 15 | MDS | 176 | Single unit: 36, double units: 140 | 56 (18–73) | / | / | 32% at 3 years | 40% at 3 years | 38% at 3 years | 28% at 3 years | 31% at 3 years | 28% at 3 years |
| Kuwatsuka et al 16 | SAA | 69 | Single unit | 49 (17‐73) | 71% at day 42 | / | / | / | 32%, | 21% at 3 years | 69% at 3 years | / |
| de Latour et al 17 | SAA | 26 | Single unit: 16, double units: 10 | 16 (9‐23) | / | / | / | 11.5% at 1 year | 45.8% | 36% at 1 year | 88.5% at 1 year | / |
| Yoshimi et al 18 | SAA | 31 | Single unit | 27.9 (0.8‐72.7) | 54.8 | 72.2% | / | / | 17.1% | 19.7% | 41.1% at 2 years | / |