TABLE 2.
Comparison of transplant effects between single‐unit and double‐unit UCBT
| Ref. | Transplant type | Patient no., conditioning | Neutrophil engraftment rate | Median neutrophil engraftment time | Grade III to IV acute GVHD | Chronic GVHD | Relapse rate | TRM | OS | LFS |
|---|---|---|---|---|---|---|---|---|---|---|
| Kindwall‐Keller et al 57 | sUCBT | 27, RIC | 85% | 25 | 19.2% | 21.7% | 59.3% | 11.1% | 35.9% | 28.6% |
| dUCBT | 23, RIC | 91% | 23 | 17.4% | 26.3% | 30.4% | 17.4% | 39.1% | 39.1% | |
| P value | / | .99 | .99 | .87 | .73 | .045 | .48 | .86 | .71 | |
| Wagner et al 58 | sUCBT | 113, MAC | 89% | 21 | 13% | 9% a | 12% | 19% | 73% | 70% |
| dUCBT | 111, MAC | 88% | 23 | 23% | 15% a | 14% | 22% | 65% | 64% | |
| P value | / | .29 | >.05 | .02 | .05 a | .12 | .43 | .17 | .11 | |
| Michel et al 59 | sUCBT | 68, MAC | 92.6% | 24.8 | 25.0% | 14.7% a | 23.5% | 5.9% | 68.8% | 67.6% |
| dUCBT | 69, MAC | 94.2% | 23.5 | 18.8% | 31.9% a | 17.4% | 11.6% | 74.8% | 68.1% | |
| P value | / | >.05 | >.05 | .40 | .02 a | .31 | .25 | .56 | .74 | |
| Baron et al 60 | sUCBT | 172, RIC | 77% | 19 | 11% | 28% | 32% | 22% | 41% | 46% |
| dUCBT | 362, RIC | 83% | 24 | 13% | 36% | 35% | 29% | 51% | 36% | |
| P value | / | .40 | <.001 | .6 | .2 | .5 | .2 | .03 | .06 | |
| Balligand et al 61 | sUCBT | 56, MAC (MRD+) | N.R. | N.R. | N.R. | N.R. | 41.7% | 19% | 53.6% | 53% |
| dUCBT | 59, MAC (MRD+) | N.R. | N.R. | N.R. | N.R. | 10.5% | 22% | 82.6% | 82.6% | |
| P value | / | N.R. | N.R. | N.R. | N.R. | .025 | .43 | .031 | .028 | |
| Zheng et al 62 | sUCBT | 60, MAC | 96.7% | 19 | 12.1% | 24.4% | 11.7% | 33.3% | 56.7% | 55.0% |
| dUCBT | 37, MAC | 89.2% | 22 | 8.7% | 28.4% | 13.5% | 54.1% | 37.8% | 32.4% | |
| P value | / | .026 | .079 | .59 | .72 | .82 | .026 | .037 | .017 |
a
Extensive chronic GVHD.
Abbreviations: dUCBT, double‐unit UCBT; GVHD, graft‐vs‐host disease; LFS, leukemia free survival; MAC, myeloablative conditioning; MRD, minimal residual disease; N.R., not reported; OS, overall survival; RIC, reduced intensified conditioning; sUCBT, single‐unit UCBT; TRM, transplant‐related mortality; UCBT, umbilical cord blood transplantation.