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Comparison of cardiotoxicity between aconitine and its converted products (mean ± SD).
| Compound | Dose (mg/kg) | VPB incubation period (s) | VT incidence (%) | Mortality (%) |
|---|---|---|---|---|
| Aconitine | 0.03 | 97.7 ± 23.7 | 100 | 0 |
| 16-Epi-pyroaconitine | 0.03 | — | 0 | 0 |
| Pyroaconitine | 0.03 | — | 0 | 0 |
| 0.13 | 134.1 ± 36.5 | 80 | 10 |
“—” means that no arrhythmias occurred within 30 min after the injection of the experimental compounds.
