Table 1.
Function of the top 10 key genes at the hub core of the PPI network.
| No | Gene | Full name | Gene functions |
|---|---|---|---|
| 1 | TTK | TTK protein kinase | Related to cell proliferation, encoding key protein for mitotic checkpoints. Abnormal mitotic spindles are produced when expression is abnormal, resulting in tumor occurring possibly. |
| 2 | CEP55 | centrosomal protein 55 | Playing roles in mitosis and cytokinesis. Related pathways include DNA damage and cytoskeleton signaling. |
| 3 | KIT | KIT proto-oncogene | Encoded protein is a type III transmembrane receptor; genetic variation is related to gastrointestinal stromal tumors and mast cells. |
| 4 | DTL | denticleless E3 ubiquitin protein | The homologue of E3 ubiquitin protein ligase, which maybe degrade PDCD4 and promote tumor development. It may be a therapeutic target for ovarian epithelial cancer. |
| 5 | E2F8 | E2F transcription factor 8 | A member of family encoding transcription factors, which regulate cell cycle-related gene expression and is involved in the promotion of a variety of tumors |
| 6 | SOX9 | SRY-box transcription factor 9 | Participated in identifying specific sequences. Related to bone deformity, nodular atypical hyperplasia and other diseases. |
| 7 | ERCC6L | excision repair 6 like | Members of family encoding protein belong to DNA transport enzymes and are necessary genes for mitotic sister chromatid isolation; involved in cell proliferation. |
| 8 | KIF18B | kinesin family member 18B | A member of the kinetin family, which constitutes the main positive end of microtubule depolymerization in mitotic cells, ensuring that the spindle is centered. |
| 9 | THY1 | Thy-1 cell surface antigen | Encoding cell surface glycoproteins and proteins, involving in adhesion and communication of multiple cell types, which promotes nasopharyngeal carcinoma. |
| 10 | CCNE1 | cyclin E1 | Encoded protein belongs to cell cycle family. Overexpression of gene is observed in many tumors, causing chromosomal instability and may promote tumorigenesis. |
Note: The annotations in this table referred to the clear conclusions in NCBI (https://www.ncbi.nlm.nih.gov/gene), and relevant scattered reports weren't included in a single literature.