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. 2021 Oct 25;2021:8293699. doi: 10.1155/2021/8293699

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Copyright © 2021 Jiawei Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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HucMSCs+ucPRP promote the recovery of ovarian endocrine function and follicular development. (a) Rat ovary and uterus after CTX treatment. (b) Rat ovarian tissue shrinkage after POF treatment. (c) Stem cells transplanted into the ovary. (d) Changes in serum E2. (e) Changes in serum FSH. (f) Changes in serum AMH. (g) Changes in the body weight of the rats. (h) HE staining of pathological sections of ovarian tissue. The black arrow points to the counted follicle. Scale bar: 500 μm, 200 μm. The pictures of healthy rat ovaries in the boxes of different colors marked in the D0 control group are enlarged and marked as (i) primordial follicle, (j) primary follicle, (k) primary follicle, and (l) antral follicle, respectively. Oo: oocyte, Gc: granulosa cell. Scale bar: 50 μm. (m) Statistical analysis of follicle counts at all levels of the D15 ovary. Data represent the mean ± SEM. ^#P > 0.05, ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.