TABLE 3.
Relative reductions in adverse outcomes in meta-analyses of intervention trials providing SQ-LNSs to children 6–24 mo of age1
| Relative reduction (95% CI), % | |
|---|---|
| Growth outcomes | |
| Stunting (LAZ < −2 SDs) | 12 (9, 15) |
| Wasting (WLZ < −2 SDs) | 14 (7, 20) |
| Underweight (WAZ < −2 SDs) | 13 (9, 17) |
| Acute malnutrition (WLZ < −2 SDs or MUAC < 125 mm) | 14 (7, 20) |
| Low MUAC (MUACZ < −2 SDs or MUAC < 125 mm) | 18 (11, 25) |
| Small head circumference (HCZ < −2 SDs) | 9 (5, 14) |
| Development outcomes2 | |
| Low language development score | 16 (8, 24) |
| Low motor development score | 16 (8, 24) |
| Low social-emotional development score | 19 (11, 26) |
| Anemia and micronutrient status outcomes | |
| Anemia (Hb <110 g/L) | 16 (13, 19) |
| Moderate-severe anemia (Hb <100 g/L) | 28 (24, 32) |
| Iron deficiency (Ferritin <12 µg/L) | 56 (50, 61) |
| Iron deficiency anemia (Hb <110 g/L and ferritin <12 µg/L) | 64 (56, 70) |
| Vitamin A deficiency (RBP <0.70 µmol/L) | 56 (30, 73) |
| Mortality | 27 (11, 41) |
1
Based on Dewey et al. [(23), growth outcomes], Prado et al. [(24), development outcomes], Wessells et al. [(25), anemia and micronutrient status outcomes], and Stewart et al. [(22), mortality]. Hb, hemoglobin; HCZ, head circumference-for-age z score; LAZ, length-for-age z score; MUAC, midupper arm circumference; MUACZ, midupper arm circumference z score; RBP, retinol binding protein; SQ-LNS, small-quantity lipid-based nutrient supplement; WAZ, weight-for-age z score; WLZ, weight-for-length z score.
2
Lowest decile defined for each study based on the within-study distribution.