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. 2021 Sep 29;114(Suppl 1):3S–14S. doi: 10.1093/ajcn/nqab279
Inclusion criteria
  • Randomized controlled trial

  • Conducted in low- or middle-income country

  • SQ-LNSs (< ∼125 kcal/d) provided to the intervention group for at least 3 mo between 6 and 24 mo of age

  • At least 1 trial group did not receive SQ-LNSs or other type of child supplementation

  • Longitudinal follow-up of each child, or repeated cross-sectional data collection

  • Individual children eligible for IPD analysis if:

  • Age at baseline allowed receipt of intervention (supplementation or control group components) for at least 3 mo between 6 and 24 mo of age

  • For anemia and micronutrient status outcomes, blood samples were collected during the supplementation period or within 3 mo after the study-defined end of supplementation

Exclusion criteria
  • LNS was used for treatment, not prevention, of malnutrition (i.e., only children with severe or moderate malnutrition were eligible for the study)

  • Conducted in a hospitalized population or among children with a pre-existing disease

  • SQ-LNS provision was combined with additional supplemental food or nutrients for the child within a single arm (e.g., SQ-LNS + food rations vs. control), and there was no appropriate comparison group (e.g., food rations alone) that would allow separation of the SQ-LNS effect from effects of the other food or nutrients provided