Table 3.
Variables in the BRS assessment
Time, min | Baseline | Post A | Post B | P (all) |
---|---|---|---|---|
Cardiovagal BRS | ||||
Slope-up, ms/mmHg | 12.3 ± 1.5 | 6.9 ± 0.8* | 6.1 ± 0.6* | <0.001 |
Slope-down, ms/mmHg | 13.4 ± 2.0 | 7.2 ± 0.8* | 6.6 ± 0.7* | <0.001 |
P (up vs. down) | 0.47 | 0.73 | 0.49 | |
Sympathetic BRS | ||||
R-BI | 0.8 ± 0.04 | 0.9 ± 0.02 | 0.9 ± 0.03 | 0.06 |
R-total MSNA | 0.8 ± 0.05 | 0.9 ± 0.02 | 0.9 ± 0.03 | 0.06 |
R-burst area | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.14 |
T50, mmHg | 80.1 ± 7.6 | 89.3 ± 1.9 | 82.9 ± 2.8 | 0.26 |
Error signal, mmHg | −5.1 ± 7.3 | 3.5 ± 2.7 | 4.4 ± 2.1 | 0.10 |
Data are presented as means ± SE; n = 10 subjects. BI, burst incidence; BMI, body mass index; BRS, baroreflex sensitivity; DBP, diastolic blood pressure; MSNA, muscle sympathetic nerve activity; R, correlation coefficient of the regression line; SBP, systolic blood pressure; T50, the midpoint pressure in the sympathetic BRS (SBRS) curve; error signal, the difference between SBRS midpoint (T50) and actual operating DBP. P (all): P value for the effect of time on the whole trial. *P < 0.05 compared with baseline by linear mixed-effects model (covariate for cardiovagal BRS; age, BMI, and SBP. Covariate for sympathetic BRS; age, BMI, and DBP).