Figure 1.

Biochemical network map showing statistically significant changes between early and late fast T0 plasma of northern elephant seal pups (n = 5 animals/period). Lipid mediators derived from omega-6 and omega-3 fatty acids are delineated on the left versus the right of the figure. Derivatives include oxylipins such as prostaglandins, thromboxanes, hydroxy acids, ketones, epoxides, and diols, in addition to endocannabinoids and endocannabinoids-like compounds such as mono-acylglycerols and N-acylethanolamides. Statistically significant changes are shown, with orange indicating an increase in concentration in late-fasted seals, whereas blue denotes a decreased concentration in late-fasted seals. Gray color indicates there was no difference between early and late fast. Fatty acid and endocannabinoid data are from previously published analysis of the same samples (4).