Table 1.
T0 plasma oxylipins affected by fasting in northern elephant seal pups
| Metabolites, nM | Early Fasted, nM | Late Fasted, nM | Cohen’s Dpooled (95% CI) | P Value | FDR |
|---|---|---|---|---|---|
| 4-HDoHE | 1.86 ± 0.409 | 7.03 ± 4.13 | −13 (−25.8, 0) | 0.00087 | 0.036 |
| 5-HEPE | 2.53 ± 0.362 | 6.17 ± 3.22 | −9.5 (−19.3, 0.2) | 0.017 | 0.10 |
| SUM_TriHOME | 4.73 ± 1.35 | 9.33 ± 2.65 | −3.3 (−7.5, 1.0) | 0.0085 | 0.062 |
| 20-HETE | 3.19 ± 1.51 | 7.95 ± 2.11 | −3.0 (−7.1, 1.0) | 0.0034 | 0.051 |
| 14,15-DiHETrE | 0.556 ± 0.132 | 0.763 ± 0.0979 | −1.4 (−4.5, 1.7) | 0.023 | 0.12 |
| 11,12-DiHETrE | 0.506 ± 0.117 | 0.684 ± 0.120 | −1.3 (−4.4, 1.7) | 0.045 | 0.21 |
| 12-HpETE | 18.1% ± 13.5 | 1.88% ± 2.26 | 0.12 (−2.7, 2.9) | 0.0088 | 0.062 |
| TXB2 | 45.6 ± 36.8 | 9.58 ± 2.93 | 0.99 (−1.9, 3.9) | 0.0037 | 0.051 |
| PGF2α | 4.58 ± 1.81 | 2.25 ± 0.520 | 1.4 (−1.7, 4.4) | 0.0049 | 0.051 |
Values are means ± SD; n = 5 animals/period. Cohen’s D effect sizes: 0.2 = small; 0.5 = medium; 0.8 = large.
12-HpETE levels were estimated based on the peak area relative response ratio response (12-HpETE peak area/internal standard peak area) and expressed as the relative abundance across all analyzed samples. While significant, the observed effect is exceedingly small.