Table 2.
Oxylipin insulin responses affected by fasting in northern elephant seal pup
| Metabolites | Early AUC (nM × min) | Late AUC (nM × min) | Cohen’s Dpooled (95% CI) | P Value | FDR |
|---|---|---|---|---|---|
| 19,20-EpDPE | 916 ± 746 | −521 ± 196 | 2.6 (0.74, 4.5) | 0.030 | 0.20 |
| 9,10-EpOME | 287 ± 270 | −241 ± 146 | 2.4 (0.6, 4.3) | 0.014 | 0.20 |
| 4-HDoHE | 755 ± 750 | −466 ± 319 | 2.1 (0.1, 3.8) | 0.024 | 0.20 |
| PGF2α | −273 ± 242 | 92.3 ± 82.3 | 2.0 (0.32, 3.7) | 0.029 | 0.20 |
| 14,15-DiHETrE | 34.7 ± 42.5 | −26.2 ± 8.83 | 2 (0.29, 3.7) | 0.031 | 0.20 |
| 12-HETE | −265 ± 4.86e3 | −1.02e4 ± 5.41e3 | 1.9 (0.26, 3.6) | 0.034 | 0.20 |
| 9,10-EpODE | 96.4 ± 135 | −160 ± 135 | 1.9 (0.23, 3.6) | 0.036 | 0.20 |
| 20-HETE | −114 ± 312 | −645 ± 291 | 1.8 (0.13, 3.4) | 0.047 | 0.20 |
| 9-HODE | −69.9 ± 460 | −886 ± 486 | 1.7 (0.1, 3.7) | 0.051 | 0.20 |
Values are means ± SD; n = 5 animals/period. Area under the curves (AUCs) were calculated based on summing polygons from concentration versus the sample time points for each metabolite as a function of time postinsulin infusion at each fasting period. One late fasting seal was not included due to missing time-point 60 (T60) values.