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. 2021 Sep 1;321(4):G426–G435. doi: 10.1152/ajpgi.00026.2021

Figure 5.

Figure 5.

ATP and 5-HT mediate epithelium-ENS interactions. A: total spontaneous movement (combined x- and y-directions) slightly decreased with the addition of 5-HT receptor antagonists (n = 6 mice; P = 0.19; paired t test). Example traces show spontaneous movement in the presence of vehicle (Bi) and 5-HT receptor antagonists (Bii). C: blue light-evoked movement decreased after the addition of 5-HT receptor antagonists (P = 0.48; paired t test). Example traces show evoked movement in the presence of vehicle (Di) that is decreased in the presence of 5-HT receptor antagonists (Dii). E: spontaneous movement significantly decreased after addition of ATP receptor antagonists (n = 4 mice; P = 0.05; paired t test). Example traces show spontaneous movement with vehicle treatment (Fi) that is decreased in the presence of ATP receptor antagonists (Fii). G: evoked movement was also significantly reduced with ATP receptor antagonists (P = 0.03; paired t test). Example traces show evoked movement with vehicle treatment (Hi) that is decreased in the presence of ATP receptor antagonists (Hii). *P < 0.05. ENS, enteric nervous system.