Figure 8.

Gene expression in chronic high-fat diet-fed Angptl4^LivKO mice after overnight fast. Fasted (18 h) mRNA expression of Angptl4 and lipases (Lpl, Lipc, Lipg, Atgl; A), fatty acid transport/synthesis markers (Cd36, Acsl1, Acsl5, Fatp2, Fatp5; B), and Ppara and downstream targets (Ppara, Pparg, Acox1, Cpt1a, Cpt2, Mcad, Vlcad; C) in livers of male Angptl4^LivKO and Angptl4^fl/fl mice fed either a normal chow diet (NCD) or a high-fat diet (HFD; 60% by kcal) for 6 mo (means ± SE; n = 5–8 mice/group). #P < 0.05, ##P < 0.01, ###P < 0.001 for dietary differences by two-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001 for individual genotype-specific differences by multiple comparison after two-way ANOVA (Tukey’s correction). EL, endothelial lipase; HL, hepatic lipase.