Table 1.

Animal models used in ANGPTL studies

	Generated Animal Models
ANGPTL3	KK/San mice with natural ANGPTL3 mutation (15) Adenovirus overexpression mouse (15) Whole body knockout mice (16–19) ANGPTL3-deficient mouse created with CRISPR base editing (20) ANGPTL3/ANGPTL8 double knockout mouse (21)
ANGPTL4	Adenovirus overexpression mice (22–24) Mouse with adenovirus overexpression of only the fibrinogen-like domain (25) Mouse with transgenic overexpression from the ApoE promoter (16) Mouse with transgenic overexpression from the AP2 promoter (26) Mouse with transgenic overexpression from the α-MHC promoter (27) Mouse with transgenic overexpression from the NPHS2 promoter (28) Whole body knockout mice (16, 29, 30) Mouse with ANGPTL4 E40K mutation (17) Adipose-specific (Adipo-Cre) knockout mice (31, 32) Brown adipose-specific (UCP1-ER-Cre) knockout mouse (33) ANGPTL4 hypomorphic mouse (EUCOMM/KOMP allele) (34)
ANGPTL8	Adenovirus overexpression mice (19, 35) Whole body knockout mice (36, 37) Whole body knockout rat (38) Mouse with human ANGPTL8 (164) Adipose-specific (Adipo-Cre) knockout mice (39) Liver-specific (Alb-Cre) knockout mice (39) ANGPTL3/ANGPTL8 double knockout mouse (21)

ANGPTL, angiopoietin-like.