Table 3.

Gene set enrichment analysis for samples collected Pre vs. 1hPost exercise

	Gene Set Name	Size	ES	NES	FDR q val.
HI: pre vs. post	HALLMARK_IL6_JAK_STAT3_SIGNALING	63	0.44	1.97	0.001
	HALLMARK_TNFA_SIGNALING_VIA_NFKB	158	0.33	1.72	0.014
	HALLMARK_HEME_METABOLISM	153	0.30	1.57	0.035
	HALLMARK_INFLAMMATORY_RESPONSE	134	0.28	1.44	0.075
	HALLMARK_ALLOGRAFT_REJECTION	140	0.27	1.41	0.074
	HALLMARK_OXIDATIVE_PHOSPHORYLATION	180	−0.51	−2.27	0.000
	HALLMARK_MYC_TARGETS_V1	190	−0.46	−2.04	0.000
	HALLMARK_FATTY_ACID_METABOLISM	132	−0.42	−1.78	0.011
	HALLMARK_ADIPOGENESIS	184	−0.38	−1.69	0.056
	HALLMARK_PEROXISOME	81	−0.43	−1.69	0.057
	HALLMARK_CHOLESTEROL_HOMEOSTASIS	62	−0.44	−1.69	0.059
	HALLMARK_MYC_TARGETS_V2	50	−0.45	−1.64	0.102
	HALLMARK_MTORC1_SIGNALING	185	−0.36	−1.61	0.144
MI: pre vs. post	HALLMARK_IL6_JAK_STAT3_SIGNALING	63	0.47	2.07	0.000
	HALLMARK_ALLOGRAFT_REJECTION	140	0.37	1.81	0.005
	HALLMARK_INTERFERON_GAMMA_RESPONSE	173	0.34	1.75	0.006
	HALLMARK_INTERFERON_ALPHA_RESPONSE	89	0.38	1.73	0.005
	HALLMARK_INFLAMMATORY_RESPONSE	134	0.34	1.66	0.011
	HALLMARK_COMPLEMENT	154	0.31	1.56	0.020
	HALLMARK_KRAS_SIGNALING_DN	63	0.35	1.53	0.022
	HALLMARK_TNFA_SIGNALING_VIA_NFKB	158	0.26	1.30	0.130
	HALLMARK_ESTROGEN_RESPONSE_EARLY	141	0.26	1.28	0.129
	HALLMARK_MYC_TARGETS_V2	50	0.30	1.22	0.194
	HALLMARK_OXIDATIVE_PHOSPHORYLATION	180	−0.39	−1.76	0.022
	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	163	−0.35	−1.55	0.120
	HALLMARK_WNT_BETA_CATENIN_SIGNALING	36	−0.44	−1.49	0.151
	HALLMARK_PEROXISOME	81	−0.37	−1.46	0.160
	HALLMARK_ADIPOGENESIS	184	−0.31	−1.38	0.247

Only pathways with FDR q val. < 0.25 are shown. Size represents the number of genes in the listed gene set. A negative normalized enrichment score (NES) represents enrichment in the precondition. ES, enrichment score; FDR q val., false-discovery rate-adjusted significance score; NES, normalized enrichment score. n = 12 subjects/group (HI: 7 F, 4 M; MI: 9 F, 3 M).