Figure 7.

Bladder outlet obstruction (BOO) causes high-pressure voiding and low flow rates that are not affected by Ac2-26 (Ac). Deobstruction (Deobs) restored normal voiding pressures and flow rates with no effect from Ac2-26. Animals were subjected to the treatment regimens described elsewhere and subjected to urodynamics. Recordings were analyzed using Med-CMG software (Catamount, St. Albans, VT). Typically, 5−10 individual micturition cycles were quantitated per animal and averaged for n = 1. A: voiding pressure = maximum pressure associated with the void. B: voiding flow rate = volume of a void divided by the duration of flow. Data are presented as means ± SE; n = 15, 13, 8, 7, 9, and 7 for both, respectively. **P < 0.01 and ***P < 0.001 by ANOVA and a Student-Newman-Keuls test. Con, control.