Figure 8.

Ac2-26 (Ac) normalizes urinary frequency and void volume in response to bladder outlet obstruction (BOO) and after deobstruction (Deobs). Animals were subjected to the treatment regimens described elsewhere and subjected to urodynamics. Recordings were analyzed using Med-CMG software (Catamount, St. Albans, VT). Typically, 5−10 individual micturition cycles were quantitated per animal and averaged for n = 1. A: voiding frequency = number of voids divided by total time for those cycles. B: void volume = total volume voided. Data are presented as means ± SE; n = 15, 13, 8, 7, 9, and 7 for all, respectively. *P < 0.05, **P < 0.01, and ***P < 0.001 by ANOVA and a Student-Newman-Keuls test. Con, control.