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. 2021 Oct 18;8:719834. doi: 10.3389/fvets.2021.719834

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Copyright © 2021 Parkhe and Verma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hemagglutinin-esterase protein of bovine coronavirus. (A) Linear order of sequence segments HE protein. F1 and F2, Fusion domains; E1 and E2, Enzyme domains; R, Receptor domain; FP, Fusion peptide; TM, Transmembrane domain. (B) Ribbon representation of HE protein. Lectin domain in orange, esterase domain in blue, and structures shown by arrows are sialic acids (sialic acid-9-O-acetylesterase) bound to lectin domain. (C) Schematic illustration of HE dimer. SA, Sialic acid; R, Receptor domain; E, Enzyme domain; MP, Membrane-proximal domain.