Table 1.

Physical and Metabolic Characteristics of Dunkin Hartley Guinea Pigs

	CONTROL	RAP	RAP+MET
Body Weight (g)	992 ± 90	846 ± 49*	775 ± 100*
Medial Tibia OARSI Score	4.6 ± 1.4	8.9 ± 3.0*	8.7 ± 3.6*
Fasted Blood Glucose (mg/dL)	242 ± 55	396 ± 61*	335 ± 53*†
Blood Rapamycin (ng/mL)	0.4 ± 0	72 ± 8	78 ± 10
Blood Metformin (ng/mL)	2 ± 0	N/A	282 ± 54

Note: Control values for Rap and Met in blood circulation are set to lowest readable value. Data are presented as mean ± SEM

^*P<0.05 vs Con.

^†P=0.05 vs Rap.