FIGURE 5.

Role of pyroptosis in tumours. Pyroptosis is a double‐edged sword in tumours. On one side, pyroptosis contributes to tumour development via GSDMC‐regulated pyroptosis with hypoxia condition or TNF‐α treatment. In contrast, pyroptosis suppresses tumour promotion by DM‐α‐KG/ CAR‐T cells/ cytotoxic CD8⁺ T cells/ cytotoxic NK cells‐induced GSDMC‐, GSDMB‐ or GSDME‐mediated pyroptosis. CAR‐T cell, Chimeric Antigen Receptor T cell; CHX, cycloheximide; DM‐α‐KG, dimethyl‐α‐ketoglutarate; DR6, death receptor 6; GzmA, granzyme A; GzmB, granzyme B; NK cells, natural killer cells; PD‐L1, programmed cell death ligand 1; STAT3, signal transducer and activator of transcription