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. 2021 Oct 19;12:733387. doi: 10.3389/fphar.2021.733387

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Copyright © 2021 Bu, Wu, Deng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between the expression and activity of SphK1 and dual role in disease. SphK1 plays different roles in different diseases. In most inflammatory diseases, the increase of pathogenic SphK1 expression intensifies the development of the disease, and SphK1 inhibitors play a therapeutic effects. The decreased expression or activity of SphK1, which has a protective effect in other diseases, contributes to the development of the other diseases (such as ischemic heart disease and HD). Therefore, normal SphK1 level is very important for the stability of body function.