Table 2.
Associations between LS7 scores and incident dementia.
| Categories of LS7 scores |
|||||
|---|---|---|---|---|---|
| Subgroups | Poor (0 to 5) | Intermediate (6 to 9) | Optimal (10 to 14) | p trend | Continuous LS7 scores |
|
| |||||
| All (n = 1987) | |||||
| No. of cases/total No. | 55/279 | 202/1367 | 34/341 | ||
| Incidence rate per 1000 person-years (95% CI) | 27.54 (20.27, 34.82) | 21.33 (18.39, 24.27) | 16.28 (10.81, 21.76) | ||
| Absolute rate difference per 1000 person-years (95% CI) | Reference | −6.22 (−14.07, 1.64) | −11.26 (−20.37, −2.15) | ||
| HR (95% CI) in Model 1 a | Reference | 0.73 (0.54, 0.99) | 0.56 (0.36, 0.87) | 0.010 | 0.92 (0.86, 0.97) |
| HR (95% CI) in Model 2 b | Reference | 0.74 (0.54, 1.00) | 0.59 (0.38, 0.91) | 0.020 | 0.92 (0.86, 0.98) |
| APOE-ε4 carrier (n = 525) | |||||
| No. of cases/total No. | 16/74 | 62/351 | 12/100 | ||
| Incidence rate per 1000 person-years (95% CI) | 30.75 (15.68, 45.82) | 26.32 (19.77, 32.88) | 22.26 (96.66, 34.86) | ||
| Absolute rate difference per 1000 person-years (95% CI) | Reference | −4.43 (−20.86, 12.00) | −8.49 (−28.13, 11.15) | ||
| HR (95% CI) in Model 1 a | Reference | 0.82 (0.47, 1.42) | 0.84 (0.39, 1.84) | 0.688 | 0.95 (0.85, 1.06) |
| HR (95% CI) in Model 2 b | Reference | 0.77 (0.43, 1.35) | 0.75 (0.34, 1.64) | 0.495 | 0.93 (0.83, 1.05) |
| APOE-ε4 noncarrier (n = 1462) | |||||
| No. of cases/total No. | 39/205 | 140/1016 | 22/241 | ||
| Incidence rate per 1000 person-years (95% CI) | 26.41 (18.12, 34.71) | 19.68 (16.42, 22.93) | 14.20 (8.27, 20.14) | ||
| Absolute rate difference per 1000 person-years (95% CI) | Reference | −6.74 (−15.65, 2.17) | −12.21 (−22.41, −2.02) | ||
| HR (95% CI) in Model 1 a | Reference | 0.70 (0.49, 1.00) | 0.47 (0.27, 0.80) | 0.006 | 0.90 (0.84, 0.97) |
| HR (95% CI) in Model 2 b | Reference | 0.72 (0.50, 1.03) | 0.49 (0.28, 0.83) | 0.009 | 0.90 (0.83, 0.97) |
Abbreviations: LS7, Life’s Simple 7; HR, hazard ratio; CI, confidence interval; APOE-ε4, apolipoprotein E genotype ε4.
a
Model 1 was adjusted for age, sex and race.
b
Model 2 was adjusted for terms in Model 1 plus education, cohort wave, calories intake, depression and APOE-ε4. APOE-ε4 allele status was not adjusted within each subgroup of APOE-ε4 noncarriers and carriers.
Values in bold mean statistically significant (p < 0.05).