Table 3.
HR (95% CI) for incident dementia associated with LS7 components.
| Categorical LS7 components |
|||||
|---|---|---|---|---|---|
| Subgroups | Poor (0) | Intermediate (1) | Optimal (2) | Continuous LS7 components | p interaction a |
|
| |||||
| All (n = 1987) b | |||||
| Diet | Reference | 0.89 (0.69, 1.14) | 0.69 (0.33, 1.44) | 0.87 (0.7, 1.09) | 0.865 |
| Physical activity | Reference | 0.67 (0.51, 0.87) | 0.59 (0.43, 0.80) | 0.75 (0.64, 0.88) | 0.614 |
| Smoking | Reference | 0.73 (0.46, 1.14) | 0.67 (0.43, 1.04) | 0.86 (0.71, 1.04) | 0.020 |
| Blood pressure | Reference | 0.93 (0.73, 1.19) | 0.79 (0.49, 1.29) | 0.91 (0.75, 1.11) | 0.932 |
| Glucose | Reference | 0.82 (0.60, 1.10) | 0.77 (0.57, 1.03) | 0.88 (0.76, 1.02) | 0.260 |
| Total cholesterol | Reference | 0.87 (0.58, 1.30) | 0.96 (0.66, 1.40) | 1.02 (0.85, 1.21) | 0.602 |
| BMI | Reference | 1.08 (0.82, 1.43) | 1.29 (0.94, 1.76) | 1.13 (0.97, 1.33) | 0.512 |
| APOE-ε4 carrier (n = 525) c | |||||
| Diet | Reference | 0.96 (0.62, 1.49) | 0.25 (0.03, 1.91) | 0.84 (0.57, 1.25) | - |
| Physical activity | Reference | 0.59 (0.36, 0.96) | 0.46 (0.25, 0.83) | 0.66 (0.49, 0.89) | - |
| Smoking | Reference | 1.58 (0.47, 5.31) | 1.55 (0.46, 5.16) | 1.07 (0.73, 1.57) | - |
| Blood pressure | Reference | 0.98 (0.61, 1.57) | 0.74 (0.28, 1.95) | 0.92 (0.63, 1.34) | - |
| Glucose | Reference | 0.99 (0.55, 1.76) | 1.00 (0.57, 1.76) | 1.00 (0.76, 1.33) | - |
| Total cholesterol | Reference | 0.87 (0.43, 1.75) | 0.78 (0.39, 1.53) | 0.89 (0.65, 1.21) | - |
| BMI | Reference | 1.20 (0.73, 1.97) | 1.40 (0.78, 2.53) | 1.19 (0.89, 1.59) | - |
| APOE-ε4 noncarrier (n = 1462) c | |||||
| Diet | Reference | 0.85 (0.63, 1.15) | 0.96 (0.43, 2.11) | 0.89 (0.67, 1.16) | - |
| Physical activity | Reference | 0.68 (0.49, 0.94) | 0.59 (0.40, 0.86) | 0.75 (0.63, 0.91) | - |
| Smoking | Reference | 0.62 (0.38, 1.02) | 0.54 (0.33, 0.87) | 0.78 (0.62, 0.97) | - |
| Blood pressure | Reference | 0.94 (0.70, 1.27) | 0.77 (0.44, 1.34) | 0.91 (0.72, 1.14) | - |
| Glucose | Reference | 0.75 (0.52, 1.07) | 0.68 (0.48, 0.96) | 0.82 (0.69, 0.98) | - |
| Total cholesterol | Reference | 0.79 (0.47, 1.31) | 0.93 (0.59, 1.48) | 1.03 (0.83, 1.28) | - |
| BMI | Reference | 1.01 (0.72, 1.42) | 1.24 (0.85, 1.80) | 1.11 (0.92, 1.34) | - |
Abbreviations: LS7, Life’s Simple 7; HR, hazard ratio; CI, confidence interval; APOE-ε4, apolipoprotein E genotype ε4.
a
Interactions were tested by adding a product term between scores of LS7 component (continuous) and APOE-ε4 allele status (dichotomous) in the adjusted Cox regression model.
b
Cox regression models were adjusted for age, sex, race, education, cohort wave, calories intake, depression and APOE-ε4 allele status.
c
Cox regression models were adjusted for age, sex, race, education, cohort wave, calories intake and depression.
Values in bold mean statistically significant (p < 0.05).