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. 2021 Oct 19;12:755366. doi: 10.3389/fphar.2021.755366

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Copyright © 2021 Zhou, Pu, Zhou and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Klotho as potential autophagy regulator and therapeutic target. The expression of Klotho can be upregulated by many exogenous and endogenous factors, some drugs, lifestyle changes and gene technology. Klotho plays a dual role in regulating autophagy (induction or inhibition) through its influence on the IGF-1/PI3K/AKT/mTOR signaling pathway, Beclin 1 expression and activity, and aldosterone level. Klotho exhibits protective effects in many diseases, making it a potential therapeutic target.