Table 1.
Demographic and clinical characteristics of the 292 patients.
| Variable | N = 292 |
|---|---|
| Age, median (IQR), years | 64.0 (55.0,73.2) |
| Male, n (%) | 201 (68.8) |
| Diagnosis at admission, n (%) | |
| CAP | 83 (28.4) |
| HAP | 66 (22.6) |
| Acute exacerbation of bronchiectasis | 44 (15.1) |
| ICH a | 44 (15.1) |
| AECOPD | 33 (11.3) |
| Lung abscess b | 22 (7.5) |
| Symptoms, n (%) | |
| Cough | 243 (83.2) |
| Sputum | 238 (81.5) |
| Fever | 200 (68.5) |
| Dyspnea | 78 (26.7) |
| Underlying Disease, n (%) | |
| Cardiovascular disease | 123 (42.1) |
| Chronic respiratory disease | 99 (33.9) |
| Diabetes | 83 (28.4) |
| ImmunosuppressionC | 60 (20.5) |
| Renal disease | 34 (11.6) |
| Liver disease | 22 (7.5) |
| Laboratory findings | |
| PCT≥0.25 ng/mL, n (%) | 175 (59.9) |
| White blood cell count,median (IQR), × 109/L | 8.4 (6.0, 12.5) |
| Neutrophil count,median (IQR), × 109/L | 6.4 (4.1, 10.4) |
| Lymphocyte count,median (IQR), × 109/L | 1.1 (0.6, 1.6) |
| Platelet count,median (IQR), × 109/L | 206.0 (150.0, 284.0) |
| Hemoglobin,median (IQR), g/L | 114.0 (94.0, 131.0) |
| ICU admission, n (%) | 150 (51.4) |
| Invasive mechanical ventilation, n (%) | 94 (32.2) |
| Current smoker, n (%) | 76 (26.0) |
| Duration from admission to sequencing, median (IQR), days |
3 (1,6) |
| Received antibiotic treatment before enrollment, n (%) | 250 (85.6) |
| Length of hospital stay, median (IQR), days | |
| In ICU | 15 (9,24) |
| In general ward | 11 (9,14) |
| Outcome, n (%) | |
| Hospital discharge | 237 (81.2) |
| Withdrawal of life support | 19 (6.5) |
| In-hospital mortality | 36 (12.3) |
Categorical variables were presented as number (percentage).
Continuous variables were presented as median (IQR, inter quartile range).
CAP, Community Acquired Pneumonia; AECOPD, Acute exacerbation of chronic obstructive pulmonary; HAP, Hospital Acquired Pneumonia; PCT, Procalcitonin;
a
Patients with CAP who are immunocompromised.
b
Among the 22 patients with Lung Abscess, 2 were immunocompromised hosts.
c
Immunosuppression: including 27 longterm steroid use, 24 receiving cancer chemotherapy, 5 solid organ transplantation, 2 primary immune deficiency diseases,2 receiving anti-rheumatic drugs or other immunosuppressive drugs.