Table 1.
Distinct features of OCC as compared with other major histotypes of ovarian cancer.
| Clear cell carcinoma | Endometrioid carcinoma | High-grade serous carcinoma | Low-grade serous carcinoma | Mucinous carcinoma | |
|---|---|---|---|---|---|
| Precursor lesions (2) | Endometriosis | Endometriosis | Serous tubal intraepithelial carcinoma (STIC) | Serous borderline tumor | Mucinous borderline tumor |
| Genetic predisposition (73, 74) | Lynch syndrome | Lynch syndrome | BRCA1/2 mutations | – | – |
| TP53 status (38, 75) | TP53 wild-type | TP53 mutations uncommon | TP53 mutant almost ubiquitous | TP53 wild-type | Both TP53 mutant and wild types exist |
| Frequent mutations and genetic changes (76–80) | ARID1A, PIK3CA, PTEN, microsatellite instability | ARID1A, PIK3CA, CTNNB1, PTEN, microsatellite instability | Genomic instability | KRAS, NRAS, BRAF, ERBB2 | KRAS, ERBB2 amplification |
Modified from (81).