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A Schematic representation of the importance of CXCL1 in neutrophil influx when the lung is challenged with K. pneumoniae. CXCL1 influences the activation of both NF-kB and MAPK which leads to an increase in MIP-2 and LIX chemokines, and other adhesion molecules such as VCAM-1 and ICAM-1. This cascade of events leads to an influx of the lungs with neutrophils followed by the clearance of the bacteria (154).
