Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 19;12:749190. doi: 10.3389/fimmu.2021.749190

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Zhou, Lawrence and Liang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The role of pDCs in tumor progression. (A) pDC recognizes CCL20 secreted by tumor cells through CCR6 on the cell membrane and makes it migrate to the tumor site. (B) Mechanisms of tumor-infiltrated pDC on immunosuppression include recruitment of immature pDCs lacking the expression of costimulatory molecules (through CCR6/CCL20 pathway), suppression of type I IFN secretion by pDCs (by ILT7L-ILT7 interaction or immunosuppressive cytokines secreted by tumor cells, such as IL-10), alternate pDC activation (through the interaction between LAG-3⁺ pDC and MHC II⁺ tumor cells), and/or promote pDC tolerance by activating Tregs (through ICOSL/ICOS interaction and IDO production) and enhancing the expression level of anti-inflammatory cytokine IL-10. In addition, the up-regulation of CXCR4 on the surface of pDC and the promotion of CXCL12 secretion by tumor cells are positively correlated with lymph node metastasis of tumor cells.