TABLE 1.

Alterations and functions of hub genes during HSC the aging process.

Gene	Aliase	Alterations with age	Functions
Aurka	Aurora kinase A	Down	Contributed to the regulation of cell cycle progression
Ccna2	Cyclin-A2	Down	Controlled both the G1/S and the G2/M transition phases of the cell cycle
Ccnb2	G2/mitotic-specific cyclin-B2	Down	Essential for the control of the cell cycle at the G2/M transition
Cdk1	Cyclin-dependent kinase 1	Down	Essential for the control of the eukaryotic cell cycle, promoted G2-M transition, and regulated G1 progress and G1-S transition
Birc5	Baculoviral IAP repeat-containing protein 5	Down	Had dual roles in promoting cell proliferation and preventing apoptosis
Jun	Transcription factor AP-1	Up	Regulated functional development of hematopoietic precursor cells into mature blood cells
Aldh1a1	Retinal dehydrogenase 1	Up	Regulated retinoic acid biosynthesis, the clearance of toxic byproducts of reactive oxygen species and HSC differentiation
Egr1	Early growth response protein 1	Up	Played a role in the regulation of cell survival, proliferation and cell death and in regulating the response to growth factors and DNA damage
Cd38	Cluster of Differentiation 38	Up	Cell adhesion and signal transduction
Junb	Transcription factor jun-B	Up	Involved in regulating gene activity following the primary growth factor response