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. 2021 Oct 19;12:732913. doi: 10.3389/fimmu.2021.732913

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Copyright © 2021 Khwatenge, Pate, Miller and Sang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunometabolic proxies underlying the association between obesity and the severe course of COVID-19. Studies have associated the propensity of severe COVID-19 manifestation in patients with obesity and relevant metabolic comorbidities. The emerging theme indicates the immuno-pathological exaggeration of predisposed immuno-metabolic disorder (indicated in the circles, especially the overlapped region on the left) in the obese COVID-19 patients. This predisposed immunometabolic disorder magnifies, locally and systemically, the virus pathogenicity and relevant immunopathies leading to more severe COVID-19 manifestations. COVID-19, coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. Created with BioRender.com.