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. 2021 Nov 1;6:72. doi: 10.1038/s41536-021-00183-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Ideal stem-cell population dynamics in the presence of adequate process control and intervention strategies. Maintenance of high-quality phenotype is critical in ensuring safety and efficacy in derived products. b Erosion of phenotype in the presence of inadequate process control and intervention, the result of which may take the form of genetic defects, elicitation of immune response by the host, abnormal function, cell cycle de-regulation, and tumorigenesis.