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. 2021 Nov 1;6:72. doi: 10.1038/s41536-021-00183-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Orchestration of phenotype is complex, depicted above in a conceptual interaction network. These interactions are illustrated to visualize the interplay between fundamental cellular processes. Ideal process control must be optimized to maintain strict homeostasis of the embryonic niche in pluripotent cell expansion bioprocessing by guiding cell network activity.