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. 2021 Nov 1;11:21380. doi: 10.1038/s41598-021-00973-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IgG antibody titers inversely correlate with parasite densities. Comparison of parasite densities estimated from Pf18s rRNA RT-qPCR analysis and the corresponding IgG (A–C) titers against Pfs230proC (A), Pfs48/45.6C (B) and EBA175RIII–V (C), and IgM (D) titers against Pfs230proC and Pfs48/45.6C. IgG, not IgM, responses were significantly inversely correlated with parasite densities. IgG Pearson r = − 0.2109**** (anti-Pfs230), r = − 0.2252**** (anti-Pfs48/45) r = − 0.2143**** (anti-EBA175). IgM Pearson r = − 0.07071 ns (Pfs230) and r = − 0.1010 ns (Pfs48/45). ^nsp > 0.05, ****p ≤ 0.0001.